2025年05月06日 星期二
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儿童肥胖或可导致成年患心脏病 |
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研究人员说，肥胖儿童早在三岁的时候就能表现出一种炎症反应，可能导致日后患上心脏病。这一发现很可能会进一步提升对儿童肥胖症的关注。 Obese children as young as age 3 show signs of an inflammatory response that has been linked to heart disease later in life, researchers said, in a finding that is likely to further stoke concerns about childhood obesity. 研究结果显示，肥胖相关疾病过程的开始时间可能比此前认为的还要早。有近30%的三至五岁肥胖儿童血液中的C反应蛋白水平升高，而相比之下，体重正常的同龄儿童则有17%的人血液中的C反应蛋白水平升高。C反应蛋白是一种被普遍研究的炎症标识物。据周一发表在《儿科学》(Pediatrics)期刊中的研究结果显示，随着儿童年龄的增长，这一差距会越来越大。 The results suggest that obesity-related disease processes may start earlier than previously believed. Nearly 30% of obese 3-to-5-year-olds had elevated blood levels of C-reactive protein -- a widely studied marker for inflammation -- compared with 17% of healthy-weight kids of the same age. The disparities widened as children aged, according to the study, which is being published Monday in the journal Pediatrics. 北卡罗来纳大学医学院儿科学教授斯金纳(Asheley Skinner)说，提高对儿童肥胖症的关注真的非常重要，甚至是在他们还很小的时候就要开始关注了，我们不能等到他们进入青春期或成年后再开始。她是这项研究报告的第一作者。 'It's really important to be concerned about childhood obesity and to even be concerned when they are quite young,' said Asheley Skinner, a professor of pediatrics at the University of North Carolina School of Medicine, who was the first author of the study. 'We can't wait until they're adolescents or adults.' 在美国，有14%的二至五岁的儿童超重，也就是在同龄组儿童中，他们的体重比至少85%的身高与他们相近的儿童都要重。 In the U.S., 14% of 2-to-5-year-olds are considered overweight, or at the 85th percentile or greater of weight for height in their age group. 据美国心脏协会(American Heart Association)的数据，C反应蛋白（CRP）显示出可以帮助预测心脏病、中风和因某些疾病而死亡的风险。此前的研究发现，超重和肥胖的成年人会出现C反应蛋白水平升高，不过对儿童C反应蛋白的情况却知之甚少。 C-reactive protein, or CRP, has been shown to help predict risk of heart disease, stroke and death under certain conditions, according to the American Heart Association. Previous studies have found that overweight and obese adults show elevated levels of CRP, but less has been known about CRP in children. 研究考察了衡量炎症不同方面的三种标识物，包括C反应蛋白；研究对象则包括全国1.6万多名年龄在1至17岁的儿童。在15至17岁前，约有60%的肥胖青少年C反应蛋白升高，而正常体重的青少年中只有18%的人C反应蛋白升高。对严重肥胖的孩子来说，C反应蛋白的上升尤其明显，有43%的幼童和83%的青少年的C反应蛋白升高。 The study examined three markers that measure different aspects of inflammation, including CRP, in more than 16,000 children nationwide between the ages of 1 and 17. By ages 15 to 17, CRP was elevated in about 60% of obese teens, compared with 18% of teens of healthy weight. The increase was even more pronounced for very obese kids, with nearly 43% of young children and 83% of teens showing CRP elevation. 其他两种炎症标识物也显示出了类似的升高模式，不过其中一种标识物直到肥胖孩子六岁后才会升高。 A similar pattern of elevation was observed for the other two inflammatory markers, though one of the markers wasn't elevated in obese children until the age of 6. 目前还不清楚，幼童体内C反应蛋白的升高是否能预测他们成年后会患心脏病。斯金纳说，对这个问题的研究需要对超重和肥胖儿童进行跟踪，直到他们成年，目前还没有进行过。不过她说，没有任何证据表明C反应蛋白的反应在儿童和成人身上会有所不同；无论年龄多大，体内的反应都是一样的。炎症是人体对感染或创伤做出的免疫反应。 It isn't known whether elevated CRP in young children will predict heart disease in adulthood. Such a study, which would involve following overweight and obese children until adulthood, hasn't been done, Dr. Skinner said. But, she said there wasn't any evidence to suggest that CRP response would be different in children than in adults; its response in the body is the same regardless of age. Inflammation is the body's immune response to infection or injury. 年龄如此小的儿童体内C反应蛋白升高，这一发现令人担心的是，其效果可能是可以累积的。据斯金纳说，需要进一步的研究来考察情况是否如此，以及减肥是否能降低儿童体内C反应蛋白的反应。该研究由美国国立卫生研究院(National Institutes of Health)资助进行。 The concern of finding CRP elevation in such young children is that its effects could be cumulative. Future research is needed to investigate whether that is the case, and also whether losing weight could reduce CRP response in kids, according to Dr. Skinner. This study was funded by the National Institutes of Health |
